Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 13/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.71 |
| ▸ | USP2 | O75604 | 9/20 | 0.71 |
| ▸ | RECQL | P46063 | 8/20 | 0.71 |
| ▸ | HPGD | P15428 | 8/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.71 |
| ▸ | THRB | P10828 | 6/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.71 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.71 |
| ▸ | MC4R | P32245 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 7/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | RAD52 | P43351 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015 | 0.98 | TDP1 (0.73) | TDP1KDM4EUSP2RECQLHPGD | |
| Isoniazid SCHEMBL5791571 | 0.89 | TDP1 (0.61) | TDP1KDM4EUSP2RECQLHPGD | |
| SCHEMBL1650332 | 0.84 | TDP1 (0.62) | TDP1KDM4EUSP2RECQLHPGD | |
| SCHEMBL12841672 | 0.84 | TDP1 (0.62) | TDP1KDM4EUSP2RECQLHPGD | |
| SCHEMBL3446 | 0.84 | TDP1 (0.62) | TDP1KDM4EUSP2RECQLHPGD | |
| SCHEMBL29537520 | 0.83 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHPGD | |
| SCHEMBL26628251 | 0.83 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHPGD | |
| SCHEMBL19555132 | 0.83 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHPGD | |
| SCHEMBL30567156 | 0.83 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHPGD | |
| SCHEMBL26597994 | 0.83 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180209956-A1 | HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180209956-A1 | HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies | RAD52, BRCA1, RAD50 | TDP1 231/4885KDM4E 3907/4885USP2 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.