Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | USP1 | O94782 | 1/20 | 0.41 |
| ▸ | USP19 | O94966 | 1/20 | 0.41 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2089931 | 0.85 | KDM4E (0.56) | SMOKDM4EALDH1A1HPGDTARBP2 | |
| SCHEMBL4260812 | 0.80 | RAB9A (0.56) | SMOKDM4EALDH1A1HPGDTARBP2 | |
| SCHEMBL4263081 | 0.80 | NR1H4 (0.51) | SMOKDM4EALDH1A1HPGDTARBP2 | |
| SCHEMBL7737825 | 0.79 | SMO (0.51) | SMOKDM4EALDH1A1HPGDTARBP2 | |
| SCHEMBL4258701 | 0.77 | KMT2A (0.63) | SMOALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL464532 | 0.70 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14431592 | 0.70 | GAA (0.54) | SMOKDM4EALDH1A1HPGDTARBP2 | |
| SCHEMBL2179708 | 0.69 | TARBP2 (0.64) | KDM4EALDH1A1HPGDTARBP2POLB | |
| SCHEMBL436384 | 0.69 | GAA (0.57) | KDM4EALDH1A1HPGDTARBP2POLB | |
| SCHEMBL5214925 | 0.69 | MAPK13 (0.58) | KDM4EALDH1A1HPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110060011-A1 | OXAZOLE COMPOUNDS COMPOSITIONS AND METHODS OF USE | AMGEN INC. (US) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060011-A1 | OXAZOLE COMPOUNDS COMPOSITIONS AND METHODS OF USE | OXA1L, CYP11B2, CYP3A7 | SMO 1063/4885KDM4E 2869/4885ALDH1A1 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.