Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 11/20 | 0.33 |
| ▸ | MMP1 | P03956 | 6/20 | 0.33 |
| ▸ | MMP3 | P08254 | 6/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.33 |
| ▸ | ADAM9 | Q13443 | 6/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10282800 | 0.87 | HSD17B10 (0.32) | NPSR1MAPTMAPK1 | |
| SCHEMBL6820707 | 0.74 | DRD3 (0.36) | ACHEMAPTPOLBTSHR | |
| SCHEMBL14861864 | 0.69 | DRD3 (0.36) | — | |
| SCHEMBL14001335 | 0.68 | ALDH1A1 (0.33) | MAPT | |
| SCHEMBL7900045 | 0.68 | HTR2A (0.38) | — | |
| SCHEMBL26346615 | 0.67 | OPRM1 (0.39) | KCNH2 | |
| SCHEMBL10211030 | 0.65 | SIGMAR1 (0.33) | — | |
| SCHEMBL10368970 | 0.65 | GSK3B (0.41) | ACHE | |
| SCHEMBL6756312 | 0.65 | NPSR1 (0.42) | ACHENPSR1KCNH2HIF1APOLB | |
| SCHEMBL21128889 | 0.65 | TSHR (0.36) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897781-B2 | Cold menthol receptor-1 antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-01 | — | — | US | disclosed |
| US-7459444-B2 | Inhibitors of chymase | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-02 | — | — | US | disclosed |
| US-20080027029-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027029-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | ACHE 1386/4885NPSR1 210/4885MMP9 3375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.