Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2872524 | 0.84 | ABCC8 (0.58) | HPGDMEN1KMT2AALDH1A1POLB | |
| SCHEMBL11536486 | 0.80 | HPGD (0.55) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL12852318 | 0.79 | ATM (0.58) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL20525051 | 0.74 | LMNA (0.67) | SMN1; SMN2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL3233775 | 0.74 | ABCC8 (0.43) | RAB9AABCC8KCNJ11 | |
| SCHEMBL2869134 | 0.74 | LMNA (0.61) | SMN1; SMN2MEN1KMT2AKDM4ERECQL | |
| SCHEMBL2868146 | 0.72 | ABCC8 (0.47) | SMN1; SMN2KDM4EALDH1A1POLBLMNA | |
| SCHEMBL12852331 | 0.72 | ATM (0.50) | ABCC8KCNJ11 | |
| SCHEMBL13938111 | 0.71 | ATM (0.52) | ABCC8KCNJ11 | |
| SCHEMBL2863854 | 0.71 | ALDH1A1 (0.51) | SMN1; SMN2MEN1KMT2ARECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034494-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-06-22 | — | — | EP | disclosed |
| US-20160102053-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-14 | — | — | US | disclosed |
| US-9108955-B2 | Heterocyclic inhibitors of necroptosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-08-18 | — | — | US | disclosed |
| US-20140128437-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-05-08 | — | — | US | disclosed |
| US-8658689-B2 | Heterocyclic inhibitors of necroptosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-02-25 | — | — | US | disclosed |
| US-20120309795-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-12-06 | — | — | US | disclosed |
| US-8278344-B2 | Heterocyclic inhibitors of necroptosis | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278344-B2 | Heterocyclic inhibitors of necroptosis | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100317701-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
| US-20100317701-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-12-16 | — | — | US | disclosed |
| US-20090099242-A1 | Heterocyclic inhibitors of necroptosis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-04-16 | — | — | US | disclosed |
| US-20090099242-A1 | Heterocyclic inhibitors of necroptosis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-04-16 | — | — | US | disclosed |
| WO-2009023272-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102053-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | SMN1; SMN2 2755/4885HPGD 888/4885MEN1 3518/4885 |
| US-20100317701-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | SMN1; SMN2 2755/4885HPGD 888/4885MEN1 3518/4885 |
| US-20090099242-A1 | Heterocyclic inhibitors of necroptosis | TNF, RIPK1, RIPK3 | SMN1; SMN2 2755/4885HPGD 888/4885MEN1 3518/4885 |
| US-20140128437-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | SMN1; SMN2 2755/4885HPGD 888/4885MEN1 3518/4885 |
| US-20120309795-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | SMN1; SMN2 2755/4885HPGD 888/4885MEN1 3518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.