Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALKBH3 | Q96Q83 | 7/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462018 | 0.89 | PDE10A (0.40) | KDM4EALKBH3HTTTDP1SMN1; SMN2 | |
| SCHEMBL2463316 | 0.88 | THRB (0.46) | KDM4EALKBH3TDP1ALDH1A1 | |
| SCHEMBL2459410 | 0.88 | NPC1 (0.43) | KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL2462220 | 0.88 | ALKBH3 (0.46) | KDM4EALKBH3SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2464343 | 0.88 | ALKBH3 (0.40) | KDM4EALKBH3ALDH1A1HPGD | |
| SCHEMBL2462203 | 0.88 | ALKBH3 (0.44) | KDM4EALKBH3HTTTDP1SMN1; SMN2 | |
| SCHEMBL2424398 | 0.87 | KDM4E (0.47) | KDM4EALKBH3HTTTDP1SMN1; SMN2 | |
| SCHEMBL2454543 | 0.86 | ADCY10 (0.44) | KDM4EALKBH3SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2456787 | 0.86 | CCR2 (0.43) | KDM4EALKBH3SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2459259 | 0.86 | CCR2 (0.51) | ALKBH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |