Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.58 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17035450 | 0.88 | SIGMAR1 (0.74) | SIGMAR1SETD7DRD1CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL10734704 | 0.79 | DRD1 (0.58) | SIGMAR1SETD7DRD1CHRM2HTR1A | |
| SCHEMBL12355565 | 0.79 | DRD1 (0.73) | SIGMAR1SETD7DRD1CHRM2HTR1A | |
| SCHEMBL7376361 | 0.74 | SIGMAR1 (1.00) | SIGMAR1DRD1CHRM2HTR1AADRA2A | |
| SCHEMBL153999 | 0.72 | MAOA (0.57) | DRD1HTR1ADRD3DRD2 | |
| SCHEMBL31841937 | 0.72 | MAOA (0.57) | DRD1HTR1ADRD3DRD2 | |
| SCHEMBL175086 | 0.69 | DRD2 (0.64) | SETD7DRD1DRD3DRD2DRD4 | |
| SCHEMBL13663060 | 0.69 | DRD1 (0.73) | SIGMAR1SETD7DRD1CHRM2HTR1A | |
| SCHEMBL23706996 | 0.67 | DRD3 (0.78) | SETD7DRD1CHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL11486011 | 0.67 | PNMT (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046145-A1 | Quinolizidinone M1 Receptor Positive Allosteric Modulators | MERCK SHARP & DOHME CORP. (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046145-A1 | Quinolizidinone M1 Receptor Positive Allosteric Modulators | CHRM1, CHRM2, OPRL1 | SIGMAR1 36/4885SETD7 3644/4885DRD1 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.