Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 8/20 | 0.73 |
| ▸ | DRD3 | P35462 | 8/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.73 |
| ▸ | HTR1A | P08908 | 4/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.73 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | SETD7 | Q8WTS6 | 5/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | DRD5 | P21918 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13663060 | 0.86 | DRD1 (0.73) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| Setiptiline SCHEMBL29414110 | 0.84 | DRD1 (1.00) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| Setiptiline SCHEMBL211362 | 0.84 | DRD1 (1.00) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| SCHEMBL10728179 | 0.80 | DRD1 (0.86) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| SCHEMBL12859693 | 0.79 | SIGMAR1 (0.58) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| SCHEMBL13921290 | 0.77 | SETD7 (0.82) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| SCHEMBL9306818 | 0.76 | SIGMAR1 (0.64) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| Hydrochloric Acid SCHEMBL9308470 | 0.75 | SIGMAR1 (0.67) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| Setiptiline SCHEMBL29396748 | 0.73 | DRD1 (0.76) | DRD1DRD3CHRM2ADRA2ACHRM1 | |
| Setiptiline SCHEMBL623015 | 0.73 | DRD1 (0.76) | DRD1DRD3CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008279-B2 | Compound—827 | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |
| US-20090012077-A1 | Novel Compound - 827 | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012077-A1 | Novel Compound - 827 | CTSS, CTSF, CTSB | DRD1 4397/4885DRD3 4559/4885CHRM2 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.