Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844635 | 0.95 | CYP19A1 (0.41) | TP53SMN1; SMN2CYP19A1ALDH1A1TSHR | |
| SCHEMBL12863854 | 0.91 | PAOX (0.45) | TP53PAOXTHRATHRBSMN1; SMN2 | |
| SCHEMBL12863834 | 0.87 | ALDH1A1 (0.46) | TP53THRATHRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL12863841 | 0.85 | CYP19A1 (0.39) | TP53PAOXSMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL10074652 | 0.85 | CYP19A1 (0.35) | TP53SMN1; SMN2CYP19A1ALDH1A1TSHR | |
| SCHEMBL25409521 | 0.83 | TP53 (0.49) | TP53PAOXTHRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL123476 | 0.81 | THRB (0.48) | TP53PAOXTHRATHRBSMN1; SMN2 | |
| SCHEMBL13485578 | 0.81 | TP53 (0.47) | TP53PAOXTHRATHRBSMN1; SMN2 | |
| SCHEMBL822424 | 0.80 | THRB (0.47) | TP53PAOXTHRATHRBSMN1; SMN2 | |
| SCHEMBL13601497 | 0.79 | THRB (0.56) | TP53PAOXTHRATHRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034434-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2011-02-10 | — | — | US | disclosed |
| US-20100120740-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120740-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120740-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, AOC1 | TP53 2774/4885PAOX 135/4885THRA 1876/4885 |
| US-20110034434-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, AOC1 | TP53 2774/4885PAOX 135/4885THRA 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.