Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.47 |
| ▸ | FOS | P01100 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12881766 | 0.81 | CNR1 (0.55) | KCNH2TMEM97SIGMAR1FOSTTR | |
| SCHEMBL12327573 | 0.81 | TRPA1 (0.53) | KCNH2TMEM97SIGMAR1FOSTTR | |
| SCHEMBL8342475 | 0.81 | TAAR1 (0.61) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL12866887 | 0.80 | KCNH2 (0.40) | KCNH2TMEM97SIGMAR1ESR1CSNK2A1 | |
| SCHEMBL13547943 | 0.80 | CSNK2A1 (0.49) | KCNH2TMEM97SIGMAR1ESR1LMNA | |
| SCHEMBL26274400 | 0.79 | CSNK2A1 (0.60) | KCNH2TMEM97SIGMAR1FOSTTR | |
| SCHEMBL13053303 | 0.79 | KCNH2 (0.48) | KCNH2TMEM97SIGMAR1FOSTTR | |
| SCHEMBL7716660 | 0.78 | ALDH1A1 (0.54) | ESR1ALOX15TAAR1TSHRMAPK1 | |
| SCHEMBL12776025 | 0.78 | CSNK2A1 (0.40) | KCNH2TMEM97SIGMAR1ESR1TSHR | |
| SCHEMBL13963701 | 0.74 | PDE10A (0.48) | FOSTTRJUNNR3C1HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130150376-A1 | Novel Sultam Compounds | PFIZER INC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-20110046160-A1 | Novel Class of Spiro Piperidines for the Treatment of Neurodegenerative Diseases | PFIZER, INC. | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150376-A1 | Novel Sultam Compounds | SULT2A1, SULT1A1, SULT1E1 | KCNH2 3499/4885TMEM97 1777/4885SIGMAR1 217/4885 |
| US-20110046160-A1 | Novel Class of Spiro Piperidines for the Treatment of Neurodegenerative Diseases | SNCA, PARK7, HTT | KCNH2 726/4885TMEM97 1020/4885SIGMAR1 1576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.