Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558509 | 0.89 | ADRA2A (0.43) | TSHRADRA2AADRA2BADRA2CCYP1A2 | |
| SCHEMBL10438954 | 0.82 | PIM1 (0.43) | ADRA2AADRA2BADRA2C | |
| SCHEMBL1178570 | 0.82 | GSK3B (0.44) | APPSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL2023829 | 0.81 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CMAOA | |
| SCHEMBL1179041 | 0.76 | MEP1B (0.43) | SMN1; SMN2ADRA2AADRA2BADRA2CCYP1A2 | |
| SCHEMBL1178523 | 0.74 | CFB (0.39) | MAPK1HPGDL3MBTL1TDP1ADRA2A | |
| SCHEMBL1178471 | 0.74 | MEN1 (0.34) | MAPK1EGFRALDH1A1HPGDL3MBTL1 | |
| SCHEMBL1179180 | 0.73 | CYP2A13 (0.41) | EGFRALDH1A1AURKARPS6KB1KDM1A | |
| SCHEMBL1178466 | 0.71 | MAPK1 (0.45) | APPMAPK1ALOX15EGFRSMN1; SMN2 | |
| SCHEMBL4217069 | 0.69 | ADRA2A (0.52) | APPMAPK1EGFRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459542-B1 | Substituted N-benzyl-4,5-dihydrooxazol-2-amines useful as selective alpha 2B/2C receptor agonists | ALLERGAN INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-8329918-B2 | Selective alpha 2B/2C agonists | ALLERGAN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329918-B2 | Selective alpha 2B/2C agonists | ALLERGAN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20110028523-A1 | Selective Alpha 2B/2C Agonists | ALLERGAN, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028523-A1 | Selective Alpha 2B/2C Agonists | ALLERGAN, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| WO-2011014332-A1 | SELECTIVE ALPHA 2B/2C AGONISTS | ALLERGAN, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028523-A1 | Selective Alpha 2B/2C Agonists | ADRA2C, ADRA2B, ADRB2 | APP 3300/4885MAPK1 3460/4885ALOX15 1914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.