Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 6/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | KDM5C | P41229 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.40 |
| ▸ | CYP8B1 | Q9UNU6 | 5/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736097 | 0.77 | KDM4C (0.54) | KDM5CKDM4CKDM4EKDM6BKDM2A | |
| SCHEMBL17144910 | 0.76 | JMJD6 (0.42) | KDM5CKDM4CKDM4EKDM6BKDM2A | |
| SCHEMBL1287025 | 0.72 | KDM5C (0.51) | KDM5CKDM4CKDM4EKDM6BKDM2A | |
| SCHEMBL1287113 | 0.72 | NPC1 (0.45) | KDM5CKDM4CKDM4EKDM6BKDM2A | |
| SCHEMBL1287029 | 0.70 | KDM4C (0.44) | KDM5CKDM4CKDM4EKDM6BKDM2A | |
| SCHEMBL1287060 | 0.70 | KDM4C (0.41) | KDM5CKDM4CKDM4EKDM6BKDM2A | |
| SCHEMBL6017370 | 0.70 | ALDH1A1 (0.47) | KDM5CKDM4CKDM4EKDM6BKDM2A | |
| SCHEMBL16380629 | 0.69 | BRD4 (0.52) | BRD4DPP4EGFRRAF1BRAF | |
| SCHEMBL1286996 | 0.69 | KDM4C (0.44) | KDM5CKDM4CKDM4EKDM6BKDM2A | |
| SCHEMBL23990564 | 0.68 | KDM4E (0.51) | KDM5CKDM4CKDM4EKDM6BKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047156-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS PLASMINOGEN INHIBITORS AND THEIR USE IN THE TREATMENT OF FIBRINOLYSIS RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-04-12 | — | — | WO | disclosed |