SCHEMBL1287484

SCHEMBL1287484

O=C(O)CCCN1CCC(OCc2ncccc2-c2ccc(Cl)cc2)CC1

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
BCHE P06276 6/20 0.47
NPY1R P25929 1/20 0.42
PTGIR P43119 1/20 0.41
TBXA2R P21731 1/20 0.40
NR1H4 Q96RI1 1/20 0.40
CARM1 Q86X55 2/20 0.39
PRMT6 Q96LA8 2/20 0.39
FFAR4 Q5NUL3 1/20 0.39
HRH3 Q9Y5N1 3/20 0.39
LTA4H P09960 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8727056 0.93 BCHE (0.44) BCHENPY1RPTGIRTBXA2RNR1H4
SCHEMBL7754987 0.80 BCHE (0.46) BCHENPY1RPTGIRNR1H4CARM1
SCHEMBL9034346 0.79 BCHE (0.39) BCHECARM1PRMT6
SCHEMBL20907004 0.76 SIGMAR1 (0.51) BCHE
SCHEMBL28087406 0.75 KCNK3 (0.37) TBXA2RHRH3
SCHEMBL15467458 0.74 SLC6A2 (0.41)
SCHEMBL10486946 0.74 LMNA (0.46)
SCHEMBL9352867 0.73 CARM1 (0.54) BCHEPTGIRCARM1PRMT6FFAR4
SCHEMBL9535263 0.72 CARM1 (0.52) BCHENPY1RCARM1PRMT6FFAR4
Bepotastine SCHEMBL29459 0.71 BCHE (0.55) BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9849121-B2 Aqueous liquid preparations and light-stabilized aqueous liquid preparations SENJU PHARMACEUTICAL CO., LTD. (JP) 2017-12-26 US disclosed
US-20170027863-A1 ORAL CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS OF BEPOTASTINE LUPIN LTD (IN) 2017-02-02 US disclosed
CN-104003978-B The industrialized process for preparing of bepotastine or its racemoid JIANGSU LIANHUAN PHARMACEUTICAL CO., LTD. (CN) 2016-01-20 CN disclosed
EP-2624836-B1 BEPOTASTINE COMPOSITIONS BAUSCH & LOMB (US) 2015-09-23 EP disclosed
US-20150031724-A1 AQUEOUS LIQUID PREPARATIONS AND LIGHT-STABILIZED AQUEOUS LIQUID PREPARATIONS SENJU PHARMACEUTICAL CO., LTD. (JP) 2015-01-29 US disclosed
US-8883825-B2 Aqueous liquid preparations and light-stabilized aqueous liquid preparations SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-11-11 US disclosed
US-8877168-B1 Aqueous liquid preparations and light-stabilized aqueous liquid preparations SENJU PHARMACEUTICALS CO., LTD. (JP) 2014-11-04 US disclosed
EP-2670387-A1 ORAL CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS OF BEPOTASTINE Lupin Limited (IN) 2013-12-11 EP disclosed
EP-2624836-A2 BEPOTASTINE COMPOSITIONS Bausch & Lomb Incorporated (US) 2013-08-14 EP disclosed
US-20130046240-A1 BEPOTASTINE COMPOSITIONS BAUSCH HEALTH AMERICAS, INC. 2013-02-21 US disclosed
US-20120322825-A1 AQUEOUS LIQUID PREPARATIONS AND LIGHT-STABILIZED AQUEOUS LIQUID PREPARATIONS SENJU PHARMACEUTICAL CO., LTD. (JP) 2012-12-20 US disclosed
WO-2012104818-A1 ORAL CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS OF BEPOTASTINE LUPIN LIMITED (IN) 2012-08-09 WO disclosed
WO-2012048059-A2 BEPOTASTINE COMPOSITIONS ISTA PHARMACEUTICALS, INC. (US) 2012-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130046240-A1 BEPOTASTINE COMPOSITIONS WASF2, NOTUM, WEE1 BCHE 25/4885NPY1R 4822/4885PTGIR 2512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.