Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AQP4 | P55087 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FABP1 | P07148 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800817 | 0.82 | TNK2 (0.52) | BTKSCN9ATNK2 | |
| SCHEMBL18800673 | 0.81 | PGR (0.53) | PLAUBTKRAB9AMEN1KMT2A | |
| SCHEMBL18800663 | 0.81 | ALDH1A1 (0.47) | PLAUBTKTNK2 | |
| SCHEMBL6116298 | 0.81 | BTK (0.63) | GCKLMNABTKTNK2 | |
| SCHEMBL18800404 | 0.80 | NPC1 (0.53) | TNK2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18800896 | 0.80 | MCL1 (0.47) | PLAUBTKTNK2 | |
| SCHEMBL1163194 | 0.79 | GCK (0.44) | GCKLMNANPC1RAB9AMEN1 | |
| SCHEMBL18800803 | 0.78 | SCN9A (0.48) | PLAUBTKSCN9AMEN1KMT2A | |
| SCHEMBL18800677 | 0.78 | MCL1 (0.46) | LMNABTKSCN9ANPC1RAB9A | |
| SCHEMBL18800806 | 0.77 | BTK (0.49) | LMNABTKTNK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2011019780-A1 | AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-17 | — | — | WO | disclosed |