Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6419015 | 0.83 | LMNA (0.71) | ALDH1A1POLBLMNAKDM4ECYP3A4 | |
| SCHEMBL411204 | 0.79 | TDP1 (0.74) | TDP1ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL1287477 | 0.78 | ALDH1A1 (0.68) | ALDH1A1POLBKMT2AMEN1TP53 | |
| SCHEMBL8752443 | 0.74 | ALDH1A1 (0.55) | ALDH1A1POLBLMNAKMT2AMEN1 | |
| SCHEMBL6137377 | 0.74 | HTR1A (0.49) | ALDH1A1POLBLMNAKDM4ECYP1A2 | |
| SCHEMBL5675703 | 0.73 | ALDH1A1 (0.51) | ALDH1A1LMNAKMT2AMEN1GAA | |
| SCHEMBL407477 | 0.73 | ALDH1A1 (1.00) | TDP1ALDH1A1POLBLMNATP53 | |
| SCHEMBL28028806 | 0.73 | MEN1 (0.90) | TDP1ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL4617734 | 0.73 | ALDH1A1 (0.63) | TDP1ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL1287370 | 0.72 | ALDH1A1 (0.59) | TDP1ALDH1A1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047926-A2 | SULFONAMIDE-CONTAINING COMPOUNDS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-04-12 | — | — | WO | disclosed |