Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 2/20 | 0.42 |
| ▸ | RARG | P13631 | 2/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25976658 | 0.83 | ALOX15 (0.47) | TRPA1MEN1KMT2AALOX15ALOX5 | |
| SCHEMBL10818080 | 0.83 | ALOX15 (0.56) | TRPA1MEN1KMT2AALOX15ALOX5 | |
| SCHEMBL23587919 | 0.83 | ALOX15 (0.56) | TRPA1MEN1KMT2AALOX15ALOX5 | |
| SCHEMBL10818084 | 0.83 | ALOX15 (0.56) | TRPA1MEN1KMT2AALOX15ALOX5 | |
| SCHEMBL16389605 | 0.81 | ALOX5 (0.42) | PTPN1TRPA1MEN1KMT2AALOX15 | |
| SCHEMBL21574083 | 0.79 | MEN1 (0.46) | TRPA1MEN1KMT2AALOX15ALOX5 | |
| SCHEMBL23587933 | 0.79 | ALOX15 (0.64) | TRPA1MEN1KMT2AALOX15ALOX5 | |
| SCHEMBL3148661 | 0.78 | MEN1 (0.44) | TRPA1MEN1KMT2AALOX15ALOX5 | |
| SCHEMBL15082353 | 0.77 | RARB (0.41) | TRPA1MEN1KMT2AALOX15ALOX5 | |
| SCHEMBL5439347 | 0.76 | MEN1 (0.39) | TRPA1MEN1KMT2AALOX15ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034554-A1 | COMPOSITIONS AND METHODS FOR TREATING MACULAR DEGENERATION | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034554-A1 | COMPOSITIONS AND METHODS FOR TREATING MACULAR DEGENERATION | NR2E3, ALDH1A2, TTPA | PTPN1 4791/4885TRPA1 3539/4885MEN1 3200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.