SCHEMBL1288073

SCHEMBL1288073

C(=Cc1ccc[nH]1)c1cc[nH]n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.39
RAB9A P51151 4/20 0.39
CHEK1 O14757 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
MAPK1 P28482 1/20 0.36
ALDH1A1 P00352 2/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
HTT P42858 2/20 0.32
NPC1 O15118 2/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1288072 1.00 MAPT (0.39) MAPTRAB9ACHEK1L3MBTL1SMN1; SMN2
SCHEMBL1288157 1.00 MAPT (0.39) MAPTRAB9ACHEK1L3MBTL1SMN1; SMN2
SCHEMBL5713386 0.81 LMNA (0.33) RAB9ASMN1; SMN2NPC1MEN1LMNA
SCHEMBL5713385 0.81 LMNA (0.33) RAB9ASMN1; SMN2NPC1MEN1LMNA
SCHEMBL2464133 0.78 MAPT (0.52) MAPTRAB9ACHEK1L3MBTL1SMN1; SMN2
SCHEMBL2464131 0.78 MAPT (0.52) MAPTRAB9ACHEK1L3MBTL1SMN1; SMN2
SCHEMBL2774574 0.73 RAB9A (0.61) MAPTRAB9AL3MBTL1MAPK1NPC1
SCHEMBL2774571 0.73 RAB9A (0.61) MAPTRAB9AL3MBTL1MAPK1NPC1
SCHEMBL1061998 0.72 KDM4E (0.55) RAB9ASMN1; SMN2ALDH1A1NPC1MEN1
SCHEMBL1240669 0.72 KDM4E (0.55) RAB9ASMN1; SMN2ALDH1A1NPC1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180009793-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP (US) 2018-01-11 US claimed
US-20140256727-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2014-09-11 US claimed
US-8772326-B2 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity Anigion Biomedica Corp. (US) 2014-07-08 US claimed
US-20140171419-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP (US) 2014-06-19 US claimed
US-20130190376-A1 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP 2013-07-25 US claimed
US-20120190668-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-07-26 US claimed
CN-102149379-A Methods of modulating hepatocyte growth factor (scatter factor) activity and small molecule modulator compositions of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP 2011-08-10 CN claimed
US-20110184038-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2011-07-28 US claimed
US-10899750-B2 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP. (US) 2021-01-26 US disclosed
US-20180009793-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP (US) 2018-01-11 US disclosed
US-20140256727-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2014-09-11 US disclosed
US-8772326-B2 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity Anigion Biomedica Corp. (US) 2014-07-08 US disclosed
US-20140171419-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP (US) 2014-06-19 US disclosed
EP-2624830-A2 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY Angion Biomedica Corp. (US) 2013-08-14 EP disclosed
US-20130190376-A1 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP 2013-07-25 US disclosed
US-20120190668-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-07-26 US disclosed
WO-2012047826-A2 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2012-04-12 WO disclosed
CN-102149379-A Methods of modulating hepatocyte growth factor (scatter factor) activity and small molecule modulator compositions of hepatocyte growth factor (scatter factor) activity ANGION BIOMEDICA CORP 2011-08-10 CN disclosed
US-20110184038-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY ANGION BIOMEDICA CORP. (US) 2011-07-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190668-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLEUCLE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC MAPT 4800/4885RAB9A 2081/4885CHEK1 3365/4885
US-20110184038-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC MAPT 4579/4885RAB9A 2231/4885CHEK1 2058/4885
US-20140256727-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC MAPT 4579/4885RAB9A 2231/4885CHEK1 2058/4885
US-10899750-B2 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity HGF, HDGF, HGFAC MAPT 4483/4885RAB9A 2133/4885CHEK1 1852/4885
US-20140171419-A1 ENHANCEMENT OF CELLULAR TRANSPLANTATION USING SMALL MOLECULE MODULATORS HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, MET MAPT 4685/4885RAB9A 3343/4885CHEK1 2887/4885
US-20180009793-A1 METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC MAPT 4579/4885RAB9A 2231/4885CHEK1 2058/4885
US-20130190376-A1 METHODS OF USE OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY HGF, HDGF, HGFAC MAPT 4662/4885RAB9A 2267/4885CHEK1 1974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.