Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 17/20 | 0.57 |
| ▸ | ABCC8 | Q09428 | 17/20 | 0.57 |
| ▸ | KCNJ11 | Q14654 | 17/20 | 0.57 |
| ▸ | KCNJ8 | Q15842 | 17/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866328 | 0.73 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL28050469 | 0.72 | PDK1 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL6359557 | 0.72 | PDK1 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL7056575 | 0.71 | PLK4 (0.48) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL2128828 | 0.71 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8489691 | 0.70 | ABCC9 (0.74) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL28077906 | 0.70 | ABCC9 (0.52) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8865688 | 0.68 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8866056 | 0.67 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL8487348 | 0.66 | ABCC9 (0.80) | ABCC9ABCC8KCNJ11KCNJ8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621526-A1 | ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS | Agensys, Inc. (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012047724-A1 | ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS | AGENSYS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |