Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 6/20 | 0.47 |
| ▸ | BCR | P11274 | 6/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 7/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907471 | 0.81 | AAK1 (0.57) | ABL1BCRGSK3B | |
| SCHEMBL12907451 | 0.74 | FGFR1 (0.70) | GSK3B | |
| SCHEMBL14397096 | 0.74 | PDPK1 (0.53) | ABL1BCRGSK3B | |
| SCHEMBL22926176 | 0.74 | ITK (0.66) | HPGDALDH1A1MAPTFLT3LRRK2 | |
| SCHEMBL12907465 | 0.74 | MAP2K4 (0.55) | ABL1BCRGSK3B | |
| SCHEMBL12907430 | 0.73 | JAK2 (0.63) | ABL1BCRGSK3B | |
| SCHEMBL12907457 | 0.73 | JAK2 (0.67) | GSK3B | |
| SCHEMBL16574176 | 0.72 | HPGD (0.73) | HPGDALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL12907468 | 0.72 | GSK3B (0.54) | ALDH1A1MAPTABL1BCRGSK3B | |
| SCHEMBL31746650 | 0.71 | DYRK1A (0.52) | HPGDALDH1A1ITKLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |