SCHEMBL12912922

SCHEMBL12912922

C[Si](C)(c1[nH]cc(-c2ccccc2)c1-c1ccccc1)c1[nH]cc(-c2ccccc2)c1-c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK8 P49336 3/20 0.41
AXL P30530 2/20 0.41
TNIK Q9UKE5 1/20 0.41
PARP1 P09874 1/20 0.40
ALDH1A1 P00352 1/20 0.39
GRM5 P41594 1/20 0.38
LRRK2 Q5S007 4/20 0.37
PRKD3 O94806 4/20 0.36
MAP4K4 O95819 4/20 0.36
CLK2 P49760 4/20 0.36
CDK5 Q00535 4/20 0.36
MAP4K2 Q12851 4/20 0.36
DYRK1A Q13627 4/20 0.36
NTRK3 Q16288 4/20 0.36
FGFR1 P11362 3/20 0.36
KDR P35968 3/20 0.36
AURKB Q96GD4 3/20 0.36
PAK4 O96013 3/20 0.36
PRKACA P17612 3/20 0.36
ROCK1 Q13464 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12912947 0.83 PDPK1 (0.34) CDK8AXLTNIKPARP1ALDH1A1
SCHEMBL12912919 0.79 PARP1 (0.39) CDK8AXLTNIKPARP1ALDH1A1
SCHEMBL9459084 0.74 HTT (0.50) CDK8AXLTNIKPARP1ALDH1A1
SCHEMBL29264066 0.74 LMNA (0.44) CDK8AXLTNIKPARP1ALDH1A1
SCHEMBL4792528 0.71 PARP1 (0.45) CDK8AXLTNIKPARP1ALDH1A1
SCHEMBL12912923 0.69 PARP1 (0.44) CDK8AXLTNIKPARP1ALDH1A1
Hydrochloric Acid SCHEMBL28338871 0.69 CHEK1 (0.44) CDK8AXLTNIKPARP1ALDH1A1
SCHEMBL12912920 0.69 ALDH1A1 (0.43) CDK8AXLTNIKPARP1ALDH1A1
SCHEMBL7217545 0.69 PARP1 (0.40) CDK8AXLTNIKPARP1ALDH1A1
SCHEMBL12912911 0.68 IMPDH2 (0.44) CDK8AXLTNIKPARP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7871714-B2 Polymer, electroluminescent device, and light emitting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2011-01-18 US disclosed
US-20090102374-A1 POLYMER, ELECTROLUMINESCENT DEVICE, AND LIGHT EMITTING DEVICE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2009-04-23 US disclosed