Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12933367 | 0.92 | LMNA (0.47) | SMN1; SMN2HPGDLMNAMEN1KMT2A | |
| SCHEMBL8345899 | 0.88 | MCHR1 (0.56) | MCHR1NPY5RPGRSMN1; SMN2HPGD | |
| SCHEMBL12933363 | 0.87 | IMPDH2 (0.54) | SMN1; SMN2MEN1KMT2ARAB9AMAPT | |
| SCHEMBL12963481 | 0.86 | MCHR1 (0.54) | MCHR1NPY5RPGRSMN1; SMN2HPGD | |
| SCHEMBL12933364 | 0.85 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2ARAB9AMAPT | |
| SCHEMBL8347783 | 0.79 | MEN1 (0.65) | MCHR1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL12963493 | 0.77 | MEN1 (0.51) | MCHR1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL13074283 | 0.76 | QPCT (0.51) | SMN1; SMN2LMNAMEN1KMT2ARAB9A | |
| SCHEMBL1058480 | 0.75 | HDAC1 (0.59) | MCHR1 | |
| SCHEMBL8348684 | 0.75 | MCHR1 (0.67) | MCHR1SMN1; SMN2HPGDLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |