Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12944600 | 0.77 | ALDH1A1 (0.35) | CRBNMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14557811 | 0.68 | CA1 (0.36) | ALDH1A1F2PRSS1 | |
| SCHEMBL7695970 | 0.68 | PNP (0.35) | CRBNMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6740222 | 0.63 | CRBN (0.56) | CRBNKMT2AALDH1A1CYP3A4MAPT | |
| SCHEMBL13536704 | 0.63 | MAOA (0.42) | MEN1KMT2AKDM4EALDH1A1TP53 | |
| SCHEMBL12060575 | 0.62 | CA2 (0.39) | — | |
| SCHEMBL28815719 | 0.62 | MAPK1 (0.43) | CRBNKMT2AKDM4EALDH1A1CYP3A4 | |
| SCHEMBL8776206 | 0.62 | CA2 (0.40) | ALDH1A1 | |
| SCHEMBL8776170 | 0.62 | CA2 (0.40) | ALDH1A1 | |
| SCHEMBL6919622 | 0.62 | MAOB (0.47) | KDM4ECYP3A4MAPTMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277873-A1 | Intermediate compound for the preparation of halichondrin analogs | Eisai R&D Management Co., Ltd. (JP) | 2011-01-26 | — | — | EP | disclosed |
| EP-2272840-A1 | Intermediate compound for the preparation of halichondrin analogs | Eisai R&D Management Co., Ltd. (JP) | 2011-01-12 | — | — | EP | disclosed |