Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.69 |
| ▸ | FPGS | Q05932 | 2/20 | 0.69 |
| ▸ | GART | P22102 | 3/20 | 0.51 |
| ▸ | NOS1 | P29475 | 6/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.44 |
| ▸ | ATIC | P31939 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13107427 | 0.92 | SOST (0.71) | SOSTFPGSGARTNOS1NOS3 | |
| SCHEMBL13181207 | 0.91 | SOST (0.69) | SOSTFPGSGARTNOS1NOS3 | |
| SCHEMBL14113468 | 0.86 | SOST (0.69) | SOSTFPGSGARTNOS1NOS3 | |
| SCHEMBL3953439 | 0.83 | SOST (0.78) | SOSTFPGSGARTNOS1NOS3 | |
| SCHEMBL15121249 | 0.83 | SOST (0.78) | SOSTFPGSGARTNOS1NOS3 | |
| SCHEMBL716106 | 0.83 | SOST (0.78) | SOSTFPGSGARTNOS1NOS3 | |
| SCHEMBL50298 | 0.83 | SOST (0.78) | SOSTFPGSGARTNOS1NOS3 | |
| Tetrahydrofolate SCHEMBL4280854 | 0.83 | SOST (0.94) | SOSTFPGSGARTDHFRMTHFD1 | |
| SCHEMBL28469783 | 0.82 | SOST (0.77) | SOSTFPGSGARTNOS1NOS3 | |
| SCHEMBL27708884 | 0.82 | SOST (0.77) | SOSTFPGSGARTNOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875716-B2 | Such as n-[4-[[2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]pseudoglutamic ester; synthesis; efficacy; reduced renal toxicity and other adverse side effects; cancer | STOICESCU DAN | 2011-01-25 | — | — | US | disclosed |
| US-20100249141-A1 | NOVEL INHIBITORS OF FOLIC ACID-DEPENDENT ENZYMES | STOICESCU DAN | 2010-09-30 | — | — | US | disclosed |
| US-7718660-B2 | Inhibitors of folic acid-dependent enzymes | STOICESCU DAN | 2010-05-18 | — | — | US | disclosed |
| US-20080214550-A1 | Novel inhibitors of folic acid-dependent enzymes | STOICESCU DAN | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249141-A1 | NOVEL INHIBITORS OF FOLIC ACID-DEPENDENT ENZYMES | FOLR2, FOLR1, DHFR | SOST 2725/4885FPGS 67/4885GART 171/4885 |
| US-20080214550-A1 | Novel inhibitors of folic acid-dependent enzymes | FOLR2, FOLR1, DHFR | SOST 2747/4885FPGS 64/4885GART 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.