Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.78 |
| ▸ | FPGS | Q05932 | 2/20 | 0.77 |
| ▸ | GART | P22102 | 5/20 | 0.58 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | ATIC | P31939 | 4/20 | 0.51 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15121249 | 1.00 | SOST (0.78) | SOSTFPGSGARTDHFRATIC | |
| SCHEMBL3953439 | 1.00 | SOST (0.78) | SOSTFPGSGARTDHFRATIC | |
| SCHEMBL50298 | 1.00 | SOST (0.78) | SOSTFPGSGARTDHFRATIC | |
| SCHEMBL28469783 | 0.99 | SOST (0.77) | SOSTFPGSGARTDHFRATIC | |
| SCHEMBL27708884 | 0.99 | SOST (0.77) | SOSTFPGSGARTDHFRATIC | |
| SCHEMBL9485867 | 0.94 | SOST (0.74) | SOSTFPGSGARTDHFRATIC | |
| Water SCHEMBL9486835 | 0.93 | SOST (0.73) | SOSTFPGSGARTDHFRATIC | |
| Homocysteine SCHEMBL27706413 | 0.93 | SOST (0.70) | SOSTFPGSGARTDHFRATIC | |
| L-Homocysteine SCHEMBL1888976 | 0.93 | SOST (0.70) | SOSTFPGSGARTDHFRATIC | |
| Glutamic Acid SCHEMBL4628258 | 0.93 | SOST (0.80) | SOSTFPGSGARTDHFRATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220016121-A1 | CRYSTALLINE SODIUM SALT OF 5-METHYL-(6S)-TETRAHYDROLIC ACID | MERCK PATENT GMBH (DE) | 2022-01-20 | — | — | US | claimed |
| CN-110475778-A | 5- methyl-(6S)-tetrahydrofolic acid crystallization sodium salt | MERCK PATENT GMBH | 2019-11-19 | — | — | CN | claimed |
| EP-2245032-B1 | FOLATES, COMPOSITIONS AND USES THEREOF | GNOSIS SPA (IT) | 2015-03-25 | — | — | EP | claimed |
| US-8524269-B2 | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions | PBM PHARMACEUTICALS, INC. (US) | 2013-09-03 | — | — | US | claimed |
| US-8173160-B2 | Improving bioabsorption, gastric acid degradation resistance; B vitamins, omega-3 fatty acids | PBM PHARMACEUTICALS, INC. (US) | 2012-05-08 | — | — | US | claimed |
| US-20120052128-A1 | ORAL COMPOSITIONS COMPRISING EDIBLE OILS AND VITAMINS AND/OR MINERALS AND METHODS FOR MAKING ORAL COMPOSITIONS | PBM PHARMACEUTICALS, INC. (US) | 2012-03-01 | — | — | US | claimed |
| US-8075910-B2 | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions | PBM PHARMACEUTICALS, INC. (US) | 2011-12-13 | — | — | US | claimed |
| US-20080274175-A1 | Compositions Comprising Edible Oils and Vitamins and/or Minerals and Methods for Making the Compositions | PBM PHARMACEUTICALS, INC. | 2008-11-06 | — | — | US | claimed |
| EP-1921930-A2 | METHODS FOR PROPHYLACTIC AND THERAPEUTIC NUTRITIONAL SUPPLEMENTATION | Everett Laboratories, Inc. (US) | 2008-05-21 | — | — | EP | claimed |
| EP-1765089-A2 | COMPOSITIONS COMPRISING EDIBLE OILS AND VITAMINS AND/OR MINERALS AND METHODS FOR MAKING THE COMPOSITIONS | PBM Pharmaceuticals, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2007021504-A2 | METHODS FOR PROPHYLACTIC AND THERAPEUTIC NUTRITIONAL SUPPLEMENTATION | EVERETT LABORATORIES, INC. (US) | 2007-02-22 | — | — | WO | claimed |
| US-20060188607-A1 | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions | PBM PHARMACEUTICALS, INC. | 2006-08-24 | — | — | US | claimed |
| WO-2005112654-A2 | COMPOSITIONS COMPRISING EDIBLE OILS AND VITAMINS AND/OR MINERALS AND METHODS FOR MAKING THE COMPOSITIONS | PBM PHARMACEUTICALS, INC. (US) | 2005-12-01 | — | — | WO | claimed |
| US-11377448-B2 | Crystalline sodium salt of 5-methyl-(6S)-tetrahydrofolic acid | MERCK PATENT GMBH (DE) | 2022-07-05 | — | — | US | disclosed |
| US-11185545-B2 | Crystalline monosodium salt of 5-methyl-(6S)-tetrahydrofolic acid | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-20210107902-A1 | CRYSTALLINE SODIUM SALT OF 5-METHYL-(6S)-TETRAHYDROFOLIC ACID | MERCK PATENT GMBH (DE) | 2021-04-15 | — | — | US | disclosed |
| WO-2009103333-A1 | PROCESS FOR THE DIASTEREOISOMERIC RESOLUTION OF 5-METHYLTETRAHYDROFOLIC ACID | GNOSIS S.P.A. (IT) | 2009-08-27 | — | — | WO | disclosed |
| CN-1039716-C | Method for the industrial preparation of (6S) folic acid derivatives by chromatographic separation | IRCA S P A IND RICHERCHE CHEMI (IT) | 1998-09-09 | — | — | CN | disclosed |
| CN-1096785-A | Commercial run by chromatographic separation preparation (6S) folic acid derivatives | IRCA S P A IND RICHERCHE CHIMI (IT) | 1994-12-28 | — | — | CN | disclosed |
| EP-0627435-A1 | Method for the industrial preparation of (6S) folic acid derivatives by chromatographic separation | ACS DOBFAR S.p.A. (IT) | 1994-12-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11185545-B2 | Crystalline monosodium salt of 5-methyl-(6S)-tetrahydrofolic acid | SLC5A6, NT5C3B, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | SOST 495/4885FPGS 146/4885GART 2379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.