Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CALCA | P06881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12952653 | 0.82 | SMN1; SMN2 (0.47) | ERCC1FEN1ERCC4SMN1; SMN2KCNE1 | |
| SCHEMBL823513 | 0.82 | ERCC1 (0.48) | ERCC1FEN1ERCC4SMN1; SMN2L3MBTL1 | |
| SCHEMBL823492 | 0.81 | KCNQ3 (0.44) | ERCC1FEN1ERCC4SMN1; SMN2L3MBTL1 | |
| SCHEMBL12952647 | 0.76 | MEN1 (0.53) | ERCC1FEN1ERCC4SMN1; SMN2KCNE1 | |
| SCHEMBL12894148 | 0.76 | PSMD14 (0.44) | ERCC1ERCC4KCNE1CCR1KCNQ1 | |
| SCHEMBL4555867 | 0.75 | SMN1; SMN2 (0.48) | ERCC1FEN1ERCC4SMN1; SMN2L3MBTL1 | |
| SCHEMBL1886479 | 0.74 | THRB (0.57) | ERCC1FEN1ERCC4SMN1; SMN2KCNE1 | |
| SCHEMBL12952738 | 0.74 | ERCC1 (0.36) | ERCC1FEN1ERCC4SMN1; SMN2L3MBTL1 | |
| SCHEMBL823370 | 0.74 | KCNE1 (0.49) | ERCC1FEN1ERCC4SMN1; SMN2KCNE1 | |
| SCHEMBL823326 | 0.74 | SMN1; SMN2 (0.47) | ERCC1FEN1ERCC4SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114903-B1 | BICYCLIC PYRIMIDINONES AND USES THEREOF | AVEXA LTD (AU) | 2011-01-26 | — | — | EP | disclosed |
| EP-2269992-A1 | Bicyclic pyrimidinones for the treatment of viral infections | Avexa Limited (AU) | 2011-01-05 | — | — | EP | disclosed |