Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12966650 | 0.88 | MAPT (0.60) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL12966537 | 0.86 | CYP1A2 (0.46) | MAPTNPC1RAB9AEPHX2GAA | |
| SCHEMBL12966652 | 0.86 | MAPT (0.51) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL11626154 | 0.78 | EPHX2 (0.66) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL12966653 | 0.77 | MAPT (0.55) | MAPTNPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL14518118 | 0.75 | LMNA (0.64) | MAPTL3MBTL1LMNAKMT2AEPHX2 | |
| SCHEMBL12966900 | 0.75 | MAPT (0.59) | MAPTNPC1RAB9ALMNAKMT2A | |
| SCHEMBL1453865 | 0.74 | LMNA (0.62) | MAPTL3MBTL1LMNAKMT2AEPHX2 | |
| SCHEMBL2475726 | 0.73 | LMNA (0.50) | MAPTNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL12611654 | 0.73 | LMNA (0.61) | MAPTL3MBTL1LMNAKMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130850-A1 | TISSUE TARGETING BY MEANS OF ONCOCIDAL BRIDGED DIPHENYL DERIVATIVES FOR THE SELECTIVE TREATMENT OF SEXUAL ORGAN TUMORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-04 | — | — | WO | disclosed |