SCHEMBL12972482

SCHEMBL12972482

COC(=O)C/C=C/CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)OC

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CASP3 P42574 3/20 0.48
▸ MDM4 O15151 2/20 0.46
▸ TP53 P04637 2/20 0.46
▸ KMT2A Q03164 1/20 0.45
▸ TNF P01375 2/20 0.44
▸ MDM2 Q00987 2/20 0.43
▸ EPHX2 P34913 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7394092 0.85 CASP3 (0.51) CASP3MDM4TP53KMT2ATNF
SCHEMBL7401573 0.85 CASP3 (0.51) CASP3MDM4TP53KMT2ATNF
SCHEMBL7399610 0.85 CASP3 (0.51) CASP3MDM4TP53KMT2ATNF
SCHEMBL7399615 0.85 CASP3 (0.51) CASP3MDM4TP53KMT2ATNF
SCHEMBL7394094 0.85 CASP3 (0.51) CASP3MDM4TP53KMT2ATNF
SCHEMBL12972480 0.84 TLR2 (0.43) CASP3MDM4TP53
SCHEMBL14047810 0.84 CASP3 (0.51) CASP3MDM4TP53KMT2AMDM2
SCHEMBL8009538 0.84 CASP3 (0.53) CASP3MDM4TP53KMT2ATNF
SCHEMBL9186701 0.83 MDM4 (0.59) CASP3MDM4TP53KMT2AMDM2
SCHEMBL8653790 0.83 MDM4 (0.59) CASP3MDM4TP53KMT2AMDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8552133-B2 Controlled polymerisation process SYNGENE LIMITED (AU) 2013-10-08 — — US disclosed
US-20100331521-A1 Controlled Polymerisation Process MONASH UNIVERSITY (AU) 2010-12-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100331521-A1 Controlled Polymerisation Process MSN, LNPEP, NGLY1 CASP3 1619/4885MDM4 168/4885TP53 2998/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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