Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TARDBP | Q13148 | 2/20 | 0.59 |
| ▸ | ACHE | P22303 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.59 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6037642 | 1.00 | HSD17B10 (0.59) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL13377696 | 0.89 | HSD17B10 (0.59) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL13377695 | 0.87 | HSD17B10 (0.57) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL27511468 | 0.84 | PPARG (0.58) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL7840306 | 0.83 | HSD17B10 (0.68) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL7843232 | 0.83 | PPARG (0.60) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL30966584 | 0.81 | ACHE (0.54) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL30966562 | 0.81 | ACHE (0.54) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL30966582 | 0.81 | ACHE (0.54) | HSD17B10KMT2ATARDBPACHECYP2C9 | |
| SCHEMBL30966589 | 0.80 | HSD17B10 (0.68) | HSD17B10KMT2ATARDBPACHECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10039743-B2 | Method of treating presbyopia using dithiol compounds and their derivatives | NOVARTIS AG (CH) | 2018-08-07 | — | — | US | disclosed |
| US-10039743-B2 | Method of treating presbyopia using dithiol compounds and their derivatives | NOVARTIS AG (CH) | 2018-08-07 | — | — | US | disclosed |
| US-20170231951-A1 | DITHIOL COMPOUNDS, DERIVATIVES, AND USES THEREFOR | ENCORE HEALTH LLC (US) | 2017-08-17 | — | — | US | disclosed |
| US-20170231951-A1 | DITHIOL COMPOUNDS, DERIVATIVES, AND USES THEREFOR | ENCORE HEALTH LLC (US) | 2017-08-17 | — | — | US | disclosed |
| US-9567314-B2 | Dithiol compounds, derivatives, and uses therefor | ENCORE HEALTH LLC (US) | 2017-02-14 | — | — | US | disclosed |
| US-9567314-B2 | Dithiol compounds, derivatives, and uses therefor | ENCORE HEALTH LLC (US) | 2017-02-14 | — | — | US | disclosed |
| US-20160264545-A1 | Dithiol Compounds, Derivatives, and Uses Therefor | ENCORE HEALTH LLC | 2016-09-15 | — | — | US | disclosed |
| US-20160264545-A1 | Dithiol Compounds, Derivatives, and Uses Therefor | ENCORE HEALTH LLC | 2016-09-15 | — | — | US | disclosed |
| US-9284305-B2 | Methods of treating ocular diseases using derivatives of lipoic acid | ENCORE HEALTH, LLC (US) | 2016-03-15 | — | — | US | disclosed |
| US-20150246903-A9 | Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid | ENCORE HEALTH LLC | 2015-09-03 | — | — | US | disclosed |
| US-20150246903-A9 | Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid | ENCORE HEALTH LLC | 2015-09-03 | — | — | US | disclosed |
| US-20140357691-A1 | Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid | ENCORE HEALTH LLC (US) | 2014-12-04 | — | — | US | disclosed |
| US-20140357691-A1 | Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid | ENCORE HEALTH LLC (US) | 2014-12-04 | — | — | US | disclosed |
| US-8795706-B2 | Methods of treating ocular diseases using derivatives of lipoic acid | ENCORE HEALTH, LLC (US) | 2014-08-05 | — | — | US | disclosed |
| US-8795706-B2 | Methods of treating ocular diseases using derivatives of lipoic acid | ENCORE HEALTH, LLC (US) | 2014-08-05 | — | — | US | disclosed |
| WO-2010147957-A2 | DITHIOL COMPOUNDS, DERIVATIVES, AND USES THEREFOR | ENCORE HEALTH, LLC (US) | 2010-12-23 | — | — | WO | disclosed |
| US-20100317608-A1 | Dithiol Compounds, Derivatives, and Uses Therefor | ENCORE HEALTH LLC (US) | 2010-12-16 | — | — | US | disclosed |
| US-20100317608-A1 | Dithiol Compounds, Derivatives, and Uses Therefor | ENCORE HEALTH LLC (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170231951-A1 | DITHIOL COMPOUNDS, DERIVATIVES, AND USES THEREFOR | FARS2, CRYZ, TALDO1 | HSD17B10 359/4885KMT2A 4596/4885TARDBP 740/4885 |
| US-20140357691-A1 | Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid | TTPA, HMGCR, CRYAB | HSD17B10 159/4885KMT2A 4128/4885TARDBP 1583/4885 |
| US-20150246903-A9 | Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid | TTPA, HMGCR, CRYAB | HSD17B10 159/4885KMT2A 4128/4885TARDBP 1583/4885 |
| US-20100317608-A1 | Dithiol Compounds, Derivatives, and Uses Therefor | FARS2, CRYZ, TALDO1 | HSD17B10 359/4885KMT2A 4596/4885TARDBP 740/4885 |
| US-10039743-B2 | Method of treating presbyopia using dithiol compounds and their derivatives | CRYAB, TXNRD3, HMGCR | HSD17B10 326/4885KMT2A 4366/4885TARDBP 840/4885 |
| US-20160264545-A1 | Dithiol Compounds, Derivatives, and Uses Therefor | FARS2, CRYZ, TALDO1 | HSD17B10 359/4885KMT2A 4596/4885TARDBP 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.