SCHEMBL129735

SCHEMBL129735

CCc1c(O)cccc1N(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.40
GAA P10253 3/20 0.40
KDM4E B2RXH2 3/20 0.40
MCL1 Q07820 1/20 0.39
EP300 Q09472 1/20 0.38
KAT2B Q92831 1/20 0.38
KAT8 Q9H7Z6 1/20 0.38
APP P05067 4/20 0.38
GABRA1 P14867 1/20 0.37
GABRB2 P47870 1/20 0.37
ALDH1A1 P00352 3/20 0.36
TSHR P16473 3/20 0.36
TP53 P04637 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CA2 P00918 3/20 0.34
CA1 P00915 2/20 0.34
CA12 O43570 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16938170 0.84 MAPT (0.48) MAPTGAAKDM4EMCL1GABRA1
SCHEMBL5134430 0.84 GAA (0.38) MAPTGAAKDM4EMCL1EP300
SCHEMBL27474264 0.83 MAPT (0.40) MAPTGAAKDM4EMCL1EP300
SCHEMBL68691 0.79 GABRA1 (0.48) MAPTKDM4EGABRA1GABRB2ALDH1A1
SCHEMBL14682132 0.79 MAPT (0.36) MAPTGAAKDM4EMCL1EP300
SCHEMBL7864623 0.77 GABRA1 (0.38) MAPTGAAKDM4EMCL1EP300
SCHEMBL8844429 0.77 GABRA1 (0.43) MAPTGAAKDM4EGABRA1GABRB2
SCHEMBL10225988 0.77 MAPT (0.41) MAPTGAAKDM4EMCL1ALDH1A1
SCHEMBL29557750 0.77 MAPT (0.41) MAPTGAAKDM4EMCL1ALDH1A1
SCHEMBL28184432 0.75 GABRA1 (0.41) MAPTGAAKDM4EGABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103382281-B Fire-retardant laminated plate IND TECH RES INST 2015-06-24 CN claimed
CN-103382281-A Fire-retardant laminated plate IND TECH RES INST 2013-11-06 CN claimed
CN-100513481-C Halogen-free phosphide-free flame-retardant thermosetting polymer material composition IND TECHNOLOGY RES INST TAIWAN (CN) 2009-07-15 CN claimed
CN-101307155-A Flame-retardant cross-linking agent and halogen-free phosphorus-free flame-retardant epoxy resin composition IND TECH RES INST (CN) 2008-11-19 CN claimed
US-20080262139-A1 Flame retardant crosslink agent and epoxy resin compositions free of halogen and phosphorous INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE 2008-10-23 US claimed
CN-1990542-A Halogen-free phosphide-free flame-retardant thermosetting polymer material composition IND TECH RES INST (CN) 2007-07-04 CN claimed
CN-1206210-C Ethyl methyl 3-[(1s)-1-(dimethylamino) ethyl] phenyl carbamate and its prepn and medicine use SHANGHAI SANWEI PHARMACEUTICAL (CN) 2005-06-15 CN claimed
US-9090624-B2 Aromatic bycyclic derivatives as CXCR4 receptor modulators ALLERGAN, INC. (US) 2015-07-28 US disclosed
CN-103382281-B Fire-retardant laminated plate IND TECH RES INST 2015-06-24 CN disclosed
WO-2014118093-A2 DYE COMPOSITION COMPRISING AT LEAST ONE PARTICULAR LIPOPHILIC META-AMINOPHENOL COUPLER IN A MEDIUM RICH IN FATTY SUBSTANCES, PROCESSES AND DEVICES L'OREAL (FR) 2014-08-07 WO disclosed
CN-103382281-A Fire-retardant laminated plate IND TECH RES INST 2013-11-06 CN disclosed
EP-1948155-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING DROXIDOPA CHELSEA THERAPEUTICS INC (US) 2012-03-07 EP disclosed
US-20120010293-A1 DROXIDOPA AND PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT OF MOOD DISORDERS, SLEEP DISORDERS, OR ATTENTION DEFICIT DISORDERS CHELSEA THERAPEUTICS, INC. 2012-01-12 US disclosed
US-5363821-A Thermoset polymer/solid lubricant coating system FORD MOTOR COMPANY (US) 1994-11-15 US disclosed
US-5358753-A Method of making an anti-friction coating on metal by plasma spraying powder having a solid lubricant core and fusable metal shell FORD MOTOR COMPANY (US) 1994-10-25 US disclosed
US-5315970-A Metal encapsulated solid lubricant coating system FORD MOTOR COMPANY (US) 1994-05-31 US disclosed
US-5302450-A Metal encapsulated solid lubricant coating system FORD MOTOR COMPANY (US) 1994-04-12 US disclosed
EP-0221925-A4 VINYL ESTER RESINS FROM GLYCIDYL ETHERS OF REACTION PRODUCT OF A PHENOL AND UNSATURATED HYDROCARBONS. DOW CHEMICAL CO (US) 1987-09-22 EP disclosed
EP-0221925-A1 VINYL ESTER RESINS FROM GLYCIDYL ETHERS OF REACTION PRODUCT OF A PHENOL AND UNSATURATED HYDROCARBONS. DOW CHEMICAL CO (US) 1987-05-20 EP disclosed
WO-1986007067-A1 VYNIL ESTER RESINS FROM GLYCIDYL ETHERS OF REACTION PRODUCT OF A PHENOL AND UNSATURATED HYDROCARBONS THE DOW CHEMICAL COMPANY (US) 1986-12-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080262139-A1 Flame retardant crosslink agent and epoxy resin compositions free of halogen and phosphorous RPL4, RFC4, PRPF4 MAPT 796/4885GAA 2766/4885KDM4E 600/4885
US-20120010293-A1 DROXIDOPA AND PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT OF MOOD DISORDERS, SLEEP DISORDERS, OR ATTENTION DEFICIT DISORDERS COMT, DRD2, TPH1 MAPT 136/4885GAA 269/4885KDM4E 233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.