Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.81 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.81 |
| ▸ | TUBB | P07437 | 7/20 | 0.81 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.81 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.81 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.81 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.81 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.81 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.81 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.81 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.81 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.81 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.81 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.81 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.81 |
| ▸ | TOP2A | P11388 | 1/20 | 0.69 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23293732 | 0.91 | TUBB1 (0.85) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12091271 | 0.91 | TUBB1 (0.85) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Thiocolchicine SCHEMBL43161 | 0.90 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Thiocolchicine SCHEMBL43160 | 0.90 | TUBB1 (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23824196 | 0.89 | TUBB1 (0.82) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23293736 | 0.89 | TUBB1 (0.82) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23824193 | 0.89 | TUBB4A (0.81) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12091258 | 0.88 | TUBB1 (0.80) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12402699 | 0.87 | TUBB1 (0.88) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Colchicine SCHEMBL2723855 | 0.87 | TUBB1 (0.95) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497290-B2 | Thiocolchicine derivatives, method of making and methods of use thereof | TAKEDA PHARMACEUTICALS U.S.A., INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497290-B2 | Thiocolchicine derivatives, method of making and methods of use thereof | TAKEDA PHARMACEUTICALS U.S.A., INC. (US) | 2013-07-30 | — | — | US | disclosed |
| WO-2010138670-A2 | THIOCOLCHICINE DERIVATIVES, METHOD OF MAKING AND METHODS OF USE THEREOF | MUTUAL PHARMACEUTICAL COMPANY, INC. (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305165-A1 | THIOCOLCHICINE DERIVATIVES, METHOD OF MAKING AND METHODS OF USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-02 | — | — | US | disclosed |
| US-20100305165-A1 | THIOCOLCHICINE DERIVATIVES, METHOD OF MAKING AND METHODS OF USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305165-A1 | THIOCOLCHICINE DERIVATIVES, METHOD OF MAKING AND METHODS OF USE THEREOF | TNNC1, TNNI3, TNNT2 | TUBB1 536/4885TUBB4A 474/4885TUBB 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.