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Sugi Predict / Compounds / SCHEMBL12982608

SCHEMBL12982608

SCHEMBL12982608

CC(C)(NC(=O)[C@H](Cc1cncn1C(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)ON1C(=O)CCC1=O

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MDM4 O15151 2/20 0.42
▸ TP53 P04637 2/20 0.42
▸ MDM2 Q00987 4/20 0.35
▸ BMP1 P13497 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12982089 0.89 MDM4 (0.47) MDM4TP53MDM2
SCHEMBL8047189 0.82 MDM4 (0.41) MDM4TP53
SCHEMBL119483 0.82 MDM4 (0.52) MDM4TP53MDM2
SCHEMBL12040111 0.82 MDM4 (0.52) MDM4TP53MDM2
SCHEMBL30195150 0.80 MDM4 (0.40) MDM4TP53MDM2
SCHEMBL30812609 0.75 PIN1 (0.42) MDM4TP53
SCHEMBL30340129 0.73 MDM2 (0.53) MDM4TP53MDM2
SCHEMBL30340355 0.73 MDM2 (0.53) MDM4TP53MDM2
SCHEMBL14969546 0.72 PTPN1 (0.46) MDM4TP53
SCHEMBL14969547 0.72 PTPN1 (0.46) MDM4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9732137-B2 Semi-recombinant preparation of GLP-1 analogues NOVO NORDISK A/S (DK) 2017-08-15 — — US disclosed
US-9732137-B2 Semi-recombinant preparation of GLP-1 analogues NOVO NORDISK A/S (DK) 2017-08-15 — — US disclosed
US-20100317057-A1 SEMI-RECOMBINANT PREPARATION OF GLP-1 ANALOGUES NOVO NORDISK A/S (DK) 2010-12-16 — — US disclosed
US-20100317057-A1 SEMI-RECOMBINANT PREPARATION OF GLP-1 ANALOGUES NOVO NORDISK A/S (DK) 2010-12-16 — — US disclosed
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