Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157898 | 0.82 | LMNA (0.44) | SPHK1TRPV1TRPA1TSHRCYP2D6 | |
| SCHEMBL3162311 | 0.80 | LMNA (0.34) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL27808029 | 0.78 | CYP2D6 (0.45) | SPHK1TRPV1TRPA1CYP2D6LMNA | |
| SCHEMBL28773249 | 0.78 | SPHK1 (0.30) | SPHK1TRPV1TRPA1 | |
| SCHEMBL427800 | 0.78 | SPHK1 (0.46) | SPHK1TSHRCYP2D6LMNAGMNN | |
| SCHEMBL30506652 | 0.78 | SPHK1 (0.46) | SPHK1TSHRCYP2D6LMNAGMNN | |
| SCHEMBL30506644 | 0.78 | SPHK1 (0.46) | SPHK1TSHRCYP2D6LMNAGMNN | |
| SCHEMBL30506676 | 0.78 | SPHK1 (0.46) | SPHK1TSHRCYP2D6LMNAGMNN | |
| SCHEMBL30506649 | 0.78 | SPHK1 (0.46) | SPHK1TSHRCYP2D6LMNAGMNN | |
| SCHEMBL3159822 | 0.77 | LMNA (0.40) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694481-B1 | IMIDAZOLE, PYRAZOLE, AND TRIAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER (US) | 2015-12-30 | — | — | EP | disclosed |
| CN-103717582-B | As the different * oxazole derivatives of antiseptic-germicide | PFIZER INC. (US) | 2015-09-30 | — | — | CN | disclosed |
| EP-2694488-B1 | ISOXAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER (US) | 2014-11-12 | — | — | EP | disclosed |
| US-8809333-B2 | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents | PFIZER INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-8748466-B2 | Isoxazole derivatives useful as antibacterial agents | PFIZER INC. (US) | 2014-06-10 | — | — | US | disclosed |
| EP-2694488-A1 | ISOXAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc (US) | 2014-02-12 | — | — | EP | disclosed |
| EP-2694481-A1 | IMIDAZOLE, PYRAZOLE, AND TRIAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc (US) | 2014-02-12 | — | — | EP | disclosed |
| US-20140038975-A1 | Imidazole, Pyrazole, and Triazole Derivatives Useful As Antibacterial Agents | BROWN MATTHEW FRANK (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140024690-A1 | Isoxazole Derivatives Useful As Antibacterial Agents | PFIZER INC. (US) | 2014-01-23 | — | — | US | disclosed |
| CN-103492368-A | imidazole, pyrazole and thiazole derivatives as antibacterial agents | PFIZER | 2014-01-01 | — | — | CN | disclosed |
| WO-2012137094-A1 | ISOXAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2012-10-11 | — | — | WO | disclosed |
| WO-2012137099-A1 | IMIDAZOLE, PYRAZOLE, AND TRIAZOLE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2012-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038975-A1 | Imidazole, Pyrazole, and Triazole Derivatives Useful As Antibacterial Agents | AADAC, TPX2, NLRP3 | SPHK1 2902/4885TRPV1 2235/4885TRPA1 3468/4885 |
| US-20140024690-A1 | Isoxazole Derivatives Useful As Antibacterial Agents | HAX1, PRXL2A, PRDX1 | SPHK1 4139/4885TRPV1 2938/4885TRPA1 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.