Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13000395 | 0.87 | KDM4E (0.44) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL12999505 | 0.80 | HDAC3 (0.46) | ALDH1A1MAPTTP53ACRHDAC3 | |
| SCHEMBL13222147 | 0.76 | KDM4E (0.54) | KDM4EHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1456726 | 0.75 | HPGDS (0.58) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL12999930 | 0.74 | GPR84 (0.41) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL24080898 | 0.73 | CREBBP (0.51) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL12999523 | 0.73 | SMN1; SMN2 (0.45) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL8532598 | 0.73 | POLB (0.54) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL12999423 | 0.73 | SMN1; SMN2 (0.45) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL3425306 | 0.73 | CYP1A2 (0.46) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305131-A1 | Substituted Aminopropionic Derivatives as Neprilysin inhibitors | NOVARTIS AG (CH) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305131-A1 | Substituted Aminopropionic Derivatives as Neprilysin inhibitors | MME, AGTR1, REN | ALDH1A1 852/4885HPGD 1610/4885KDM4E 2452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.