Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13222147 | 0.77 | KDM4E (0.54) | KDM4EPOLBLMNA | |
| SCHEMBL24080898 | 0.77 | CREBBP (0.51) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL12999390 | 0.77 | MLYCD (0.39) | GPR84SMN1; SMN2MCL1MAPTCYP1A2 | |
| SCHEMBL21754889 | 0.77 | GPR84 (0.67) | GPR84MAPTKDM4EMLYCDALOX15 | |
| SCHEMBL12999915 | 0.74 | ENPP2 (0.43) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL12999511 | 0.74 | KMT2A (0.39) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3425306 | 0.74 | CYP1A2 (0.46) | SMN1; SMN2MCL1MAPTCYP1A2CYP3A4 | |
| SCHEMBL12999481 | 0.74 | ALDH1A1 (0.45) | SMN1; SMN2MCL1MAPTCYP1A2CYP3A4 | |
| SCHEMBL8532608 | 0.73 | ALDH1A1 (0.47) | SMN1; SMN2MAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6778647 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2MCL1MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305131-A1 | Substituted Aminopropionic Derivatives as Neprilysin inhibitors | NOVARTIS AG (CH) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305131-A1 | Substituted Aminopropionic Derivatives as Neprilysin inhibitors | MME, AGTR1, REN | GPR84 1165/4885SMN1; SMN2 1020/4885MCL1 4314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.