Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061120 | 0.85 | LTA4H (0.49) | LTA4HSLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL13005432 | 0.82 | OPRM1 (0.44) | ALDH1A1GAAL3MBTL1OPRM1OPRD1 | |
| SCHEMBL13005691 | 0.81 | OPRM1 (0.43) | OPRM1OPRD1OPRK1 | |
| SCHEMBL18828594 | 0.81 | LTA4H (0.60) | LTA4HSLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL13005597 | 0.74 | ALDH1A1 (0.42) | SLC6A2SLC6A4SLC6A3KMT2AALDH1A1 | |
| SCHEMBL16640979 | 0.74 | ALDH1A1 (0.50) | SLC6A2SLC6A4SLC6A3ALDH1A1ACHE | |
| SCHEMBL13005625 | 0.74 | BCHE (0.47) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL16191031 | 0.73 | EED (0.40) | ALDH1A1GAAL3MBTL1OPRM1OPRD1 | |
| SCHEMBL13005541 | 0.72 | OPRM1 (0.44) | MEN1KMT2AACHEOPRM1OPRD1 | |
| SCHEMBL13005440 | 0.72 | CALM1 (0.59) | SLC6A2SLC6A4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |