Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.66 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.66 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007335 | 1.00 | MTNR1A (0.66) | MTNR1AMTNR1BCSF1RPDGFRBFLT4 | |
| SCHEMBL13007334 | 0.90 | MTNR1A (0.52) | MTNR1AMTNR1BABCB1CTSLCTSB | |
| SCHEMBL13007336 | 0.90 | MTNR1A (0.52) | MTNR1AMTNR1BABCB1CTSLCTSB | |
| SCHEMBL16328854 | 0.80 | TNF (0.53) | MTNR1AMTNR1BMAPTPOLBLMNA | |
| SCHEMBL13007341 | 0.80 | MTNR1A (1.00) | MTNR1AMTNR1BCSF1RPDGFRBFLT4 | |
| SCHEMBL14149433 | 0.78 | TNF (0.48) | MTNR1AMTNR1BMAPTPOLBLMNA | |
| SCHEMBL13007333 | 0.75 | TNF (0.46) | MTNR1AMTNR1BMAPTLMNA | |
| SCHEMBL14106255 | 0.72 | TNF (0.47) | MTNR1AMTNR1BMAPTPOLBLMNA | |
| SCHEMBL9922451 | 0.70 | KDM4E (0.49) | MTNR1AMTNR1BMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL9922460 | 0.70 | TXNRD1 (0.46) | MTNR1AMTNR1BMAPTSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389544-B2 | Isoquinolone compounds as subtype-selective agonists for melatonin receptors MT1 and MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2013-03-05 | — | — | US | disclosed |
| US-8389544-B2 | Isoquinolone compounds as subtype-selective agonists for melatonin receptors MT1 and MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2013-03-05 | — | — | US | disclosed |
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-12-16 | — | — | US | disclosed |
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-12-16 | — | — | US | disclosed |
| WO-2008092292-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | MTNR1A, MTNR1B, MC2R | MTNR1A 1/4885MTNR1B 2/4885CSF1R 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.