Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 1.00 |
| ▸ | MTNR1B | P49286 | 1/20 | 1.00 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007345 | 0.90 | MTNR1B (0.81) | MTNR1AMTNR1BCNR2POLBABCB1 | |
| SCHEMBL13007327 | 0.87 | MTNR1A (0.77) | MTNR1AMTNR1BBCHEMEN1KMT2A | |
| SCHEMBL13007340 | 0.81 | MTNR1A (0.68) | MTNR1AMTNR1BMAOBMAOABCHE | |
| SCHEMBL13007337 | 0.80 | MTNR1A (0.66) | MTNR1AMTNR1BMAOBPKMMAOA | |
| SCHEMBL13007335 | 0.80 | MTNR1A (0.66) | MTNR1AMTNR1BMAOBPKMMAOA | |
| SCHEMBL13061402 | 0.74 | CNR2 (0.59) | MTNR1AMTNR1BGRM2NPC1RAB9A | |
| SCHEMBL13007331 | 0.73 | MTNR1A (0.58) | MTNR1AMTNR1BNPC1RAB9ACNR2 | |
| SCHEMBL27972960 | 0.70 | MTNR1A (0.54) | MTNR1AMTNR1BHTR1AADRA1DADRA1A | |
| SCHEMBL13047167 | 0.69 | POLB (0.67) | MTNR1AMTNR1BGRM2MEN1KMT2A | |
| SCHEMBL15957895 | 0.69 | TP53 (0.55) | MTNR1AMTNR1BNPC1POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389544-B2 | Isoquinolone compounds as subtype-selective agonists for melatonin receptors MT1 and MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2013-03-05 | — | — | US | disclosed |
| US-8389544-B2 | Isoquinolone compounds as subtype-selective agonists for melatonin receptors MT1 and MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2013-03-05 | — | — | US | disclosed |
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-12-16 | — | — | US | disclosed |
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-12-16 | — | — | US | disclosed |
| WO-2008092292-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | MTNR1A, MTNR1B, MC2R | MTNR1A 1/4885MTNR1B 2/4885MAOB 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.