Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061402 | 0.80 | CNR2 (0.59) | MTNR1AMTNR1BCNR2TP53POLB | |
| SCHEMBL13007327 | 0.78 | MTNR1A (0.77) | MTNR1AMTNR1BCNR2TP53MAPT | |
| SCHEMBL13007345 | 0.76 | MTNR1B (0.81) | MTNR1AMTNR1BCNR2TP53POLB | |
| SCHEMBL13007341 | 0.73 | MTNR1A (1.00) | MTNR1AMTNR1BCNR2TP53POLB | |
| SCHEMBL3783034 | 0.71 | MTNR1A (0.48) | MTNR1AMTNR1BCNR2KDM5CTP53 | |
| SCHEMBL28322540 | 0.68 | ALDH1A1 (0.50) | TP53POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL17832018 | 0.68 | SMN1; SMN2 (0.59) | KDM5AKDM5CPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL3771039 | 0.68 | MTNR1A (0.45) | MTNR1AMTNR1BCNR2TP53MAPT | |
| SCHEMBL14106258 | 0.68 | MTNR1A (0.45) | MTNR1AMTNR1BCNR2TP53POLB | |
| SCHEMBL9394915 | 0.67 | GAA (0.53) | MTNR1AMTNR1BTP53POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389544-B2 | Isoquinolone compounds as subtype-selective agonists for melatonin receptors MT1 and MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2013-03-05 | — | — | US | disclosed |
| US-8389544-B2 | Isoquinolone compounds as subtype-selective agonists for melatonin receptors MT1 and MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2013-03-05 | — | — | US | disclosed |
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-12-16 | — | — | US | disclosed |
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-12-16 | — | — | US | disclosed |
| WO-2008092292-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317691-A1 | ISOQUINOLONE COMPOUNDS AS SUBTYPE-SELECTIVE AGONISTS FOR MELATONIN RECEPTORS MT1 AND MT2 | MTNR1A, MTNR1B, MC2R | MTNR1A 1/4885MTNR1B 2/4885CNR2 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.