Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1950623 | 0.98 | HRH3 (0.48) | HRH3DRD3PAOXRAB9ASLC29A1 | |
| SCHEMBL10388024 | 0.93 | HRH3 (0.46) | HRH3DRD3PAOXRAB9ASLC29A1 | |
| Hydrochloric Acid SCHEMBL3107158 | 0.91 | PAOX (0.53) | HRH3DRD3PAOXRAB9ASLC29A1 | |
| SCHEMBL10387010 | 0.89 | ALDH1A1 (0.49) | HRH3DRD3PAOXRAB9ASLC29A1 | |
| SCHEMBL8560879 | 0.85 | KDM4E (0.51) | HRH3RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL8562390 | 0.83 | CYP2D6 (0.54) | HRH3RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL16845085 | 0.83 | HRH3 (0.50) | HRH3DRD3PAOXRAB9ASLC29A1 | |
| SCHEMBL11025698 | 0.82 | HRH3 (0.47) | HRH3DRD3PAOXRAB9ASLC29A1 | |
| SCHEMBL14641556 | 0.81 | HRH3 (0.49) | HRH3DRD3PAOXRAB9ASLC29A1 | |
| SCHEMBL24219772 | 0.80 | HRH3 (0.48) | HRH3DRD3PAOXRAB9ASLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877751-B2 | Benzothiazolone derivatives | MERCK PATENT GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| EP-2150539-B1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-12-18 | — | — | EP | disclosed |
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-11-03 | — | — | US | disclosed |
| US-20110136819-A1 | 6-THIOXOPYRIDAZINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2011-06-09 | — | — | US | disclosed |
| US-20100179148-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-07-15 | — | — | US | disclosed |
| WO-2009024221-A1 | 6-THIOXO-PYRIDAZINE DERIVATIVES | MERCK PATENT GBMH (DE) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179148-A1 | PYRIDAZINONE DERIVATIVES | MET, ERBB2, RET | HRH3 1571/4885DRD3 2521/4885PAOX 3021/4885 |
| US-20110269756-A1 | BENZOTHIAZOLONE DERIVATIVES | RET, JAK2, MET | HRH3 2083/4885DRD3 2820/4885PAOX 3514/4885 |
| US-20110136819-A1 | 6-THIOXOPYRIDAZINE DERIVATIVES | RET, ABL1, JAK2 | HRH3 2891/4885DRD3 3168/4885PAOX 3551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.