Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9942257 | 0.83 | ALDH1A1 (0.48) | RAB9AHPGDTDP1KMT2AMEN1 | |
| SCHEMBL14997451 | 0.80 | CA2 (0.58) | HPGDTDP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL24653097 | 0.79 | L3MBTL1 (0.51) | CTBP2RAB9AL3MBTL1NPC1TDP1 | |
| SCHEMBL17040103 | 0.78 | GFER (0.42) | RAB9ATDP1ALDH1A1MAPTCNR2 | |
| SCHEMBL13272365 | 0.78 | ALDH1A1 (0.40) | CTBP2TDP1KMT2AALDH1A1GAA | |
| SCHEMBL15372403 | 0.78 | CES2 (0.44) | CTBP2ALDH1A1GAALMNA | |
| SCHEMBL13741321 | 0.78 | CTBP2 (0.53) | CTBP2RAB9AL3MBTL1NPC1HPGD | |
| SCHEMBL13272118 | 0.78 | HTT (0.59) | CTBP2NPC1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7832793 | 0.77 | CES1 (0.58) | CTBP2L3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL4940818 | 0.77 | L3MBTL1 (0.62) | CTBP2RAB9AL3MBTL1NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258366-A2 | Quinoline derivatives and quinazoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same | Kirin Pharma Kabushiki Kaisha (JP) | 2010-12-08 | — | — | EP | disclosed |
| EP-1411046-B1 | QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING SELF-PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICINAL COMPOSITION CONTAINING THE SAME | KIRIN PHARMA KK (JP) | 2009-09-16 | — | — | EP | disclosed |
| WO-2007000550-A2 | NOVEL INDOLINE COMPOUNDS | LABORATOIRES FOURNIER S.A. (FR) | 2007-01-04 | — | — | WO | disclosed |