Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26474681 | 0.92 | ALDH1A1 (0.53) | SMN1; SMN2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL11468077 | 0.86 | TP53 (0.62) | SMN1; SMN2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL3497661 | 0.86 | LMNA (0.47) | SMN1; SMN2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL20014923 | 0.85 | MAPK1 (0.58) | SMN1; SMN2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL2989345 | 0.84 | LMNA (0.51) | SMN1; SMN2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL14882857 | 0.83 | ADRA2A (0.52) | SMN1; SMN2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL29072069 | 0.83 | LMNA (0.51) | SMN1; SMN2MAPTPKMALDH1A1MEN1 | |
| SCHEMBL6030589 | 0.83 | TSHR (0.47) | SMN1; SMN2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL4158380 | 0.82 | NPSR1 (0.52) | SMN1; SMN2MAPTTSHRPKMALDH1A1 | |
| SCHEMBL2984306 | 0.82 | ALDH1A1 (0.52) | SMN1; SMN2MAPTTSHRALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331335-A1 | Inhibitors of Jun N-Terminal Kinase | ELAN PHARMACETICALS, INC. | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331335-A1 | Inhibitors of Jun N-Terminal Kinase | CHUK, MAPK6, MAPK3 | SMN1; SMN2 2311/4885MAPT 51/4885TSHR 4502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.