Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13024512 | 0.90 | KDM4E (0.51) | KDM4ETDP1L3MBTL1USP2POLB | |
| SCHEMBL9653929 | 0.74 | KMT2A (0.67) | TDP1L3MBTL1POLBMAPTKMT2A | |
| SCHEMBL2665689 | 0.72 | TDP1 (0.63) | KDM4ETDP1L3MBTL1POLBMAPT | |
| SCHEMBL21240899 | 0.69 | KDM4E (0.64) | KDM4ETDP1L3MBTL1USP2POLB | |
| SCHEMBL18062419 | 0.68 | NPC1 (0.66) | KDM4ETDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL507242 | 0.68 | RAB9A (0.66) | KDM4ETDP1L3MBTL1POLBMAPT | |
| SCHEMBL28327199 | 0.68 | NPC1 (0.66) | KDM4ETDP1L3MBTL1POLBKMT2A | |
| SCHEMBL1192767 | 0.68 | TDP1 (0.58) | KDM4ETDP1L3MBTL1USP2POLB | |
| SCHEMBL192332 | 0.67 | NPC1 (1.00) | KDM4ETDP1L3MBTL1POLBKMT2A | |
| SCHEMBL29944113 | 0.67 | LMNA (0.67) | KDM4ETDP1L3MBTL1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993718-B2 | Methods and compositions for detecting and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140187444-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-07-03 | — | — | US | disclosed |
| US-8524444-B2 | Methods and compositions for detections and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-03 | — | — | US | disclosed |
| US-20100290987-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100290987-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | OGA, IAPP, IDE | KDM4E 2545/4885TDP1 2142/4885L3MBTL1 2659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.