Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4932919 | 0.90 | SLC6A2 (0.57) | ALDH1A1CYP1A2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3684866 | 0.86 | ALDH1A1 (0.53) | ALDH1A1CYP1A2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2097664 | 0.83 | ALDH1A1 (0.60) | ALDH1A1CYP1A2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28750304 | 0.82 | MMP2 (0.43) | ALDH1A1HDAC3HDAC1HDAC2SLC2A1 | |
| SCHEMBL27527322 | 0.82 | HSD17B3 (0.51) | ALDH1A1CYP1A2SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL10467094 | 0.81 | MMP2 (0.48) | ALDH1A1HTTHDAC3HDAC1HDAC2 | |
| SCHEMBL648332 | 0.80 | CES2 (0.47) | ALDH1A1SLC6A2SLC6A3HTTMMP9 | |
| SCHEMBL5193603 | 0.79 | GSK3B (0.53) | ALDH1A1CYP1A2KMT2ATAS1R3TAS1R1 | |
| SCHEMBL541916 | 0.79 | CES2 (0.54) | ALDH1A1CYP1A2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL514175 | 0.79 | ALDH1A1 (0.58) | ALDH1A1CYP1A2KMT2AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2772488-B1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | INST PHARM & TOXICOLOGY AMMS (CN) | 2016-11-02 | — | — | EP | disclosed |
| EP-2772488-A1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L. A. China (CN) | 2014-09-03 | — | — | EP | disclosed |
| US-8053581-B2 | Trisubstituted thiazole compounds, preparations methods, pharmaceutical compositions and medicals uses thereof | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.C. China (CN) | 2011-11-08 | — | — | US | disclosed |
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2009-12-03 | — | — | US | disclosed |
| EP-2042494-A1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2009-04-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | CETP, PLTP, MTTP | ALDH1A1 2114/4885CYP1A2 603/4885SLC6A2 2708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.