Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.85 |
| ▸ | RAB9A | P51151 | 2/20 | 0.85 |
| ▸ | CASP3 | P42574 | 1/20 | 0.70 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.70 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.70 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | DPP4 | P27487 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.59 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.59 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.59 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11776953 | 0.95 | NPC1 (0.82) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1304210 | 0.92 | NPC1 (1.00) | NPC1RAB9APDE4BMAPTKMT2A | |
| SCHEMBL8200487 | 0.92 | NPC1 (0.71) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL4612572 | 0.87 | NPC1 (0.74) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL2928400 | 0.85 | NPC1 (0.87) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL9320692 | 0.84 | RAB9A (0.64) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL4483889 | 0.83 | NPC1 (0.77) | NPC1RAB9APDE4BMAPTKMT2A | |
| SCHEMBL7868896 | 0.83 | NPC1 (0.83) | NPC1RAB9APDE4BMAPTL3MBTL1 | |
| SCHEMBL8896007 | 0.83 | TDP1 (0.68) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL28650296 | 0.83 | RAB9A (0.82) | NPC1RAB9APDE4BMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2772488-B1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | INST PHARM & TOXICOLOGY AMMS (CN) | 2016-11-02 | — | — | EP | disclosed |
| EP-2772488-A1 | 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L. A. China (CN) | 2014-09-03 | — | — | EP | disclosed |
| EP-2042494-B1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | INST PHARM & TOXICOLOGY AMMS (CN) | 2014-07-09 | — | — | EP | disclosed |
| US-8053581-B2 | Trisubstituted thiazole compounds, preparations methods, pharmaceutical compositions and medicals uses thereof | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.C. China (CN) | 2011-11-08 | — | — | US | disclosed |
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2009-12-03 | — | — | US | disclosed |
| EP-2042494-A1 | 2,4,5-TRISUBSTITUTED THIAZOLE COMPOUNDS,PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. (CN) | 2009-04-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298832-A1 | TRISUBSTITUTED THIAZOLE COMPOUNDS, PREPARATIONS METHODS, PHARMACEUTICAL COMPOSITIONS AND MEDICALS USES THEREOF | CETP, PLTP, MTTP | NPC1 148/4885RAB9A 4686/4885CASP3 1449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.