Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.64 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166019 | 0.93 | RAB9A (0.69) | RAB9ANPC1TDP1GPR52MEN1 | |
| SCHEMBL8269548 | 0.85 | HSD11B1 (0.64) | RAB9ANPC1TDP1MEN1KMT2A | |
| SCHEMBL27628173 | 0.84 | RAB9A (0.69) | RAB9ANPC1TDP1GPR52MEN1 | |
| SCHEMBL4884872 | 0.84 | PDE4B (0.62) | RAB9ANPC1ALDH1A1HSD11B1HTR1A | |
| SCHEMBL28188567 | 0.84 | PDE4B (0.67) | RAB9ANPC1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL1303471 | 0.84 | NPC1 (0.85) | RAB9ANPC1TDP1CASP3SENP8 | |
| SCHEMBL4638591 | 0.82 | CES2 (0.59) | RAB9ANPC1MAPTPOLBHSD11B1 | |
| SCHEMBL1515775 | 0.82 | MEN1 (0.61) | RAB9ANPC1TDP1GPR52MEN1 | |
| SCHEMBL3138472 | 0.81 | CES2 (0.57) | RAB9ANPC1TDP1KMT2AALDH1A1 | |
| SCHEMBL15194958 | 0.81 | CDYL2 (0.51) | RAB9ANPC1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310268-B1 | Substituted cycloalkanols | AMERICAN HOME PROD (US) | 1994-02-02 | — | — | EP | disclosed |
| US-4826844-A | ANTIDEPRESSANT, ANXIOLYTIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| US-4745191-A | 1-((A-substituted phenyl-ω-substituted piperazinyl)alkenyl) cyclohexanol | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-17 | — | — | US | disclosed |