Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 8/20 | 0.38 |
| ▸ | HTR1B | P28222 | 7/20 | 0.38 |
| ▸ | HTR1D | P28221 | 6/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13050847 | 0.83 | CYP2D6 (0.53) | TRPM8MAPTHTR6LTA4HPLA2G2A | |
| SCHEMBL13050886 | 0.79 | LTA4H (0.36) | MAPTALDH1A1LTA4HMTNR1ACYP2D6 | |
| SCHEMBL741863 | 0.74 | LTA4H (0.46) | TRPM8MAPTALDH1A1GAAHTR6 | |
| SCHEMBL649226 | 0.72 | HTR2A (0.53) | MAPTALDH1A1HTR6SLC6A4HTR1A | |
| SCHEMBL6280803 | 0.71 | HTR2A (0.58) | MAPTALDH1A1GAAHTR6SLC6A4 | |
| SCHEMBL25307628 | 0.70 | MPO (0.60) | TRPM8SLC6A4HTR1AMTNR1AMTNR1B | |
| SCHEMBL8111779 | 0.67 | HTR1D (0.62) | HTR1BHTR1D | |
| SCHEMBL14092936 | 0.66 | HTT (0.38) | ALDH1A1 | |
| SCHEMBL8902207 | 0.66 | HTR1D (0.64) | HTR1AHTR1BHTR1DHTR7 | |
| SCHEMBL5338731 | 0.65 | SLC6A4 (0.55) | MAPTALDH1A1HTR6SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399465-B2 | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase | JANSSEN PHARMACEUTICA NV (BE) | 2013-03-19 | — | — | US | disclosed |
| US-20100292208-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292208-A1 | COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | LTA4H, LTC4S, LTB4R | TRPM8 861/4885MAPT 4429/4885ALDH1A1 1950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.