Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.57 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.57 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.55 |
| ▸ | FBP1 | P09467 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24869474 | 1.00 | APOBEC3A (0.57) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL12344114 | 1.00 | APOBEC3A (0.57) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL11772242 | 1.00 | APOBEC3A (0.57) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL171200 | 0.98 | PDK1 (0.54) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL2666128 | 0.93 | — | — | |
| SCHEMBL7325816 | 0.76 | APOBEC3A (0.61) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL17339864 | 0.76 | NPC1 (0.34) | APOBEC3AAPOBEC3GPDK1FBP1NPC1 | |
| SCHEMBL17339862 | 0.76 | PDE10A (0.35) | APOBEC3AAPOBEC3GPDK1FBP1NPC1 | |
| SCHEMBL10965367 | 0.74 | APOBEC3A (0.59) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL17028600 | 0.74 | APOBEC3A (0.59) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331283-A1 | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331283-A1 | Mitotic kinesin inhibitors and methods of use thereof | KIF5B, KIF2C, KIFC1 | APOBEC3A 3608/4885APOBEC3G 3650/4885PDK1 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.