Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398220 | 0.81 | IDO1 (0.56) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL1802749 | 0.80 | IDO1 (0.60) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL1547586 | 0.80 | TP53 (0.48) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL11621292 | 0.79 | IDO1 (0.65) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL2097653 | 0.79 | IDO1 (0.65) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL165560 | 0.78 | IDO1 (0.69) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL29984975 | 0.78 | IDO1 (0.69) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL9455806 | 0.78 | IDO1 (0.38) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL401356 | 0.78 | IDO1 (0.52) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 | |
| SCHEMBL283639 | 0.77 | IDO1 (0.62) | IDO1CYP1A2CYP3A4CYP2C9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 802 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11919854-B2 | P2RX7 modulators in therapy | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2024-03-05 | — | — | US | claimed |
| CN-112867706-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2021-05-28 | — | — | CN | claimed |
| EP-3802489-A2 | MASP-2 INHIBITORS AND METHODS OF USE | Omeros Corporation (US) | 2021-04-14 | — | — | EP | claimed |
| CN-112512520-A | P2RX7 modulators in therapy | 国家科学研究中心 | 2021-03-16 | — | — | CN | claimed |
| EP-3773557-A1 | P2RX7 MODULATORS IN THERAPY | Centre national de la recherche scientifique (FR) | 2021-02-17 | — | — | EP | claimed |
| US-20210017131-A1 | P2RX7 MODULATORS IN THERAPY | JUNIA (FR) | 2021-01-21 | — | — | US | claimed |
| WO-2020196767-A1 | FOAMED MULTILAYER SHEET, UNFOAMED MULTILAYER SHEET, FUNGICIDE, AND RESIN COMPOSITION | 大日本印刷株式会社 | 2020-10-01 | — | — | WO | claimed |
| US-20200215194-A1 | APOPTOSIS INHIBITOR FORMULATIONS FOR PREVENTION OF HEARING LOSS | SPIRAL THERAPEUTICS, INC. | 2020-07-09 | — | — | US | claimed |
| CN-111362932-A | Isothiazole oxadiazole amide derivatives and preparation method and application thereof | 南开大学 | 2020-07-03 | — | — | CN | claimed |
| US-10561736-B1 | Apoptosis inhibitor formulations for prevention of hearing loss | SPIRAL THERAPEUTICS, INC. (US) | 2020-02-18 | — | — | US | claimed |
| US-5976894-A | FOR SCREENING BIOASSAYS TO DISCOVER BIOLOGICALLY ACTIVE MEMBERS | PHARMACOPEIA, INC. (US) | 1999-11-02 | — | — | US | claimed |
| US-5401766-A | Hypotensive agents with vasodilation | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | claimed |
| EP-0328160-B1 | Amino acid derivatives, process to prepare them, composition containing them and their use | HOECHST AG (DE) | 1994-05-04 | — | — | EP | claimed |
| US-5192783-A | Fungicides for plants | ROHM AND HAAS COMPANY (US) | 1993-03-09 | — | — | US | claimed |
| EP-0378615-A4 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | — | 1992-04-08 | — | — | EP | claimed |
| EP-0378615-A1 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | COMPETITIVE TECHNOLOGIES INC. (US) | 1990-07-25 | — | — | EP | claimed |
| EP-0046953-B1 | AMINO ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-12-06 | — | — | EP | claimed |
| WO-1989011486-A1 | NUCLEOSIDE AND POLYNUCLEOTIDE THIOPHOSPHORAMIDITE AND PHOSPHORODITHIOATE COMPOUNDS AND PROCESSES | UNIVERSITY PATENTS, INC. (US) | 1989-11-30 | — | — | WO | claimed |
| EP-0328160-A1 | Amino acid derivatives, process to prepare them, composition containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-16 | — | — | EP | claimed |
| EP-0278530-A2 | Amino acid derivatives, process for their preparation, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-17 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017131-A1 | P2RX7 MODULATORS IN THERAPY | P2RX3, P2RX7, P2RX2 | IDO1 1464/4885CYP1A2 931/4885CYP3A4 1084/4885 |
| US-10561736-B1 | Apoptosis inhibitor formulations for prevention of hearing loss | APAF1, API5, CASP9 | IDO1 2938/4885CYP1A2 4559/4885CYP3A4 4755/4885 |
| US-11919854-B2 | P2RX7 modulators in therapy | P2RX7, P2RX2, P2RX1 | IDO1 1389/4885CYP1A2 881/4885CYP3A4 929/4885 |
| US-20200215194-A1 | APOPTOSIS INHIBITOR FORMULATIONS FOR PREVENTION OF HEARING LOSS | APAF1, API5, CASP9 | IDO1 2938/4885CYP1A2 4559/4885CYP3A4 4755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.