Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | OGG1 | O15527 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305881 | 0.92 | ALDH1A1 (0.41) | TSHRCNR2ALDH1A1HPGDKDM4E | |
| SCHEMBL1306814 | 0.80 | CNR2 (0.38) | TSHRCNR2CNR1ALDH1A1HPGD | |
| SCHEMBL1305135 | 0.79 | P2RX3 (0.46) | TSHRALDH1A1HPGDKDM4ETDP1 | |
| SCHEMBL27762737 | 0.78 | TSHR (0.40) | TSHRALDH1A1HPGDKDM4ETDP1 | |
| SCHEMBL1306705 | 0.78 | TSHR (0.40) | TSHRALDH1A1HPGDKDM4ETDP1 | |
| SCHEMBL12113399 | 0.76 | ALDH1A1 (0.53) | TSHRCNR2CNR1ALDH1A1HPGD | |
| SCHEMBL1308300 | 0.76 | MEN1 (0.45) | TSHRCNR2CNR1ALDH1A1HPGD | |
| SCHEMBL1308296 | 0.76 | MEN1 (0.45) | TSHRCNR2CNR1ALDH1A1HPGD | |
| SCHEMBL3816498 | 0.76 | ALDH1A1 (0.44) | TSHRCNR2ALDH1A1HPGDKDM4E | |
| SCHEMBL1306822 | 0.75 | TSHR (0.38) | TSHRALDH1A1HPGDKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |