Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1306705 | 0.90 | TSHR (0.40) | TSHRALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL27762737 | 0.90 | TSHR (0.40) | TSHRALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL1305135 | 0.85 | P2RX3 (0.46) | TSHRALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL1306823 | 0.80 | TRPM4 (0.38) | TRPM4ALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL1307997 | 0.78 | P2RX3 (0.62) | TSHRALDH1A1KDM4EHPGDP2RX3 | |
| SCHEMBL1305881 | 0.78 | ALDH1A1 (0.41) | TSHRALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL1306160 | 0.76 | KMT2A (0.45) | TSHRTRPM4ALDH1A1KDM4EHPGD | |
| SCHEMBL1306812 | 0.75 | TSHR (0.39) | TSHRALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL3821011 | 0.73 | TSHR (0.43) | TSHRALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL1307088 | 0.73 | P2RX3 (0.44) | TRPM4ALDH1A1KDM4EPOLBG6PD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053435-B2 | Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-11-08 | — | — | US | disclosed |