Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18618469 | 0.81 | KDM1A (0.44) | HTR2CKDM1APLGMEN1KMT2A | |
| SCHEMBL30228493 | 0.81 | HTR2C (0.64) | L3MBTL1HTR2CP2RY14KDM1APLG | |
| SCHEMBL23858275 | 0.81 | HTR2C (0.64) | L3MBTL1HTR2CP2RY14KDM1APLG | |
| Hydrochloric Acid SCHEMBL4891806 | 0.80 | HTR2C (0.65) | L3MBTL1HTR2CP2RY14PLG | |
| Hydrochloric Acid SCHEMBL4891821 | 0.80 | HTR2C (0.65) | L3MBTL1HTR2CP2RY14PLG | |
| Hydrochloric Acid SCHEMBL4891832 | 0.80 | HTR2C (0.65) | L3MBTL1HTR2CP2RY14PLG | |
| SCHEMBL2298335 | 0.79 | HTR2C (0.61) | L3MBTL1HTR2CP2RY14NISCHEPHX1 | |
| Hydrochloric Acid SCHEMBL4893644 | 0.78 | HTR2C (0.62) | L3MBTL1HTR2CP2RY14KDM1ARCOR1 | |
| SCHEMBL9176241 | 0.77 | L3MBTL1 (0.46) | L3MBTL1HRH3KDM1ARCOR1GRIN2B | |
| SCHEMBL25307338 | 0.76 | HTR3A (0.54) | HTR2CEPHX1SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |